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Semax

Synthetic ACTH(4-10) analogue — nasal nootropic

Protocol Summary

Route
Nasal
Dose Range
200–600 mcg/day
Cycling
10–20 days on, 10 days off
Evidence Tier
human-obs

Primary Benefits

Safety Profile

Well-tolerated. Nasal irritation possible. Approved in Russia/Ukraine for clinical use.

Research Findings

from peptide_kb — updated weekly

expert-opinion expert-opinion (1)

Semax and PT-141 mentioned as ineffective against SSRI-induced sexual dysfunction
youtube 2026-04-04 source →
In discussing SSRI side effects (60% sexual dysfunction rate), the speaker briefly mentions that 'you can take all the Semax and PT-141 you want' — implying these peptides cannot overcome SSRI-induced sexual dysfunction because the root cause is systemic serotonin dysregulation affecting the entire neuroendocrine system, not just localized sexual function.

clinical-anecdotal clinical-anecdotal (1)

Peptides vs Supplements for Cognitive Enhancement — Dihexa, P21, Semax, Selank
youtube 2026-06-07 source →
Supplement formulator compares neuropeptides to traditional nootropics. Dihexa described as 'hundreds of times more powerful than lion's mane' for neurogenesis. P21+Dihexa combined in 'Neurorigen' product. Semax compared to alpha-GPC but far more potent. All peptides positioned as tools to combat neurodegenerative disease beyond what supplements alone can achieve. Also discusses dopamine resensitization via Semax, P21, Dihexa.