Activin A and Myostatin as Endogenous Muscle Growth Suppressors via ActR2
Activin A and myostatin are endogenous proteins that bind to the ActR2 receptor on muscle cells and signal through the SMAD2/3 cascade to suppress or limit muscle growth. The body uses these signals as a natural brake on muscle hypertrophy. Bimagrumab's therapeutic rationale is built on blocking these inhibitory ligands. No dosage figures are applicable as these are endogenous proteins.