Cagrilintide

The speaker mentions cagrilintide as a potential third agent that may be added to the tirzepatide and retatrutide combination for select patients, suggesting a triple-peptide stacking protocol. No specific patient selection criteria, dosages, or frequencies are provided. This is presented as a clinical option within a personalized approach.

Dr. Jones reports seeing patients in retatrutide communities combining it with cagrilintide (an amylin analog) on top of retatrutide. While he states there can be strategic low-dose stacking approaches, combining these without understanding which receptors are activated, at what doses, and without monitoring side effects is dangerous guessing with a triple agonist.

When asked whether AOD-9604 and cagrilintide can be combined, Dr. Jones confirms it is possible but expresses a preference for other GLP-1 options over cagrilintide ('Kaggy'). He frames this as theoretically acceptable but not his first-choice protocol.

The speaker describes Cagrilintide as an extremely effective appetite suppressant, characterizing it as a 'nuclear bomb' solution for appetite control problems. No specific dosage, protocol, or mechanism of action is provided in this excerpt. The claim is presented as a recommendation rather than being backed by cited clinical data or personal clinical experience with patients.