CGRP involvement in neuroimmune eczema cascade and overlap with fibromyalgia/RA
Calcitonin gene-related peptide (CGRP) is released by skin nerve fibers alongside Substance P and directly stimulates mast cell degranulation. Dr. Bachmeyer notes CGRP is also implicated in fibromyalgia and rheumatoid arthritis, framing it as part of a shared neuroimmune dysfunction pattern across barrier-failure diseases.