Larazotide (Larazotide Acetate) Mechanism: Directly Inhibits Zonulin-Mediated Tight Junction Opening
Larazotide is described as working directly on the zonulin signaling pathway, which is the signal that instructs tight junctions in the gut lining to open. Rather than patching the gut wall externally, it turns down the signal that keeps tight junctions open, representing a mechanistically distinct approach from other gut-healing peptides. The speaker distinguishes this from BPC-157 and KPV, which do not act on this pathway.