Leptin

Citing a study in the Annals of Internal Medicine, the speaker reports that two nights of 4-hour sleep caused Leptin (satiety hormone) to drop by 18% and Ghrelin (hunger hormone) to rise by 28%. This hormonal shift increased hunger ratings by 24% and cravings for high-carb foods by 30-45%.

Leptin, produced by fat cells, signals satiety to the brain. The speaker describes a mechanism where chronic high leptin levels (due to excess fat) or inflammation 'jams' the brain's ability to hear this signal, effectively turning down the volume of the satiety response. This leads the brain to perceive starvation despite high body fat.

Campbell briefly mentions Leptin as a forthcoming compound in the same category of interest as Follistatin, suggesting it is on the horizon for discussion or use. No specific application, dosage, mechanism, or protocol is elaborated upon in this excerpt. The mention is speculative and forward-looking rather than based on current clinical use.