Tesofensine

The speaker discusses tesofensine (captioned 'testophencin' or 'teslens'), noting it is not a peptide. It inhibits the reuptake of dopamine, norepinephrine and serotonin. He used it for appetite suppression when he could not raise his GLP-1 dose further. [Audit 2026-10-04: originally misidentified as Teprenone/Testolactone; the triple reuptake mechanism is tesofensine's]

The speaker reports significant side effects from this compound, including increased heart rate, insomnia, jitteriness, restlessness, mood instability, and anxiety. He warns that it should be avoided by those who already have sleep issues due to its long half-life and nervous system stimulation. [Audit 2026-10-04: compound is tesofensine (see the mechanism finding from the same video)]